Ingredients 2025-09-22 • 4 min read

When to Start Retinol and Vitamin C: Practical Age-Based Guidance

Retinol and vitamin C are two of the most popular skincare actives, but the right time to start depends on your skin goals, sensitivity, and how consistent you can be. This guide gives practical age-based starting points and simple routines that work.

Key takeaways

There is no single perfect age. Many people start in their mid 20s to early 30s for prevention, or earlier for acne if tolerated.
Start with one active at a time, low strength, and build consistency before increasing intensity.
Vitamin C is usually a morning active. Retinoids are usually nighttime actives.
If you are pregnant or trying to conceive, avoid retinoids unless your clinician advises otherwise.

When to start vitamin C

Vitamin C is generally well tolerated and can be started whenever you want brighter tone, antioxidant support, or help with post-acne marks. Many people begin in their early 20s, especially if they spend time outdoors. If you are sensitive, choose a gentler derivative and use it a few times per week to start.

When to start retinol or retinoids

Retinol (and prescription retinoids) can improve acne, texture, fine lines, and uneven tone, but they can also irritate. Practical starting points:

Teens to early 20s: Often started for acne under guidance, especially prescription retinoids.
Mid 20s to early 30s: Common time to start for prevention and early texture concerns.
30s and beyond: Still highly effective. The best time to start is when you can be consistent and protect with sunscreen.

A simple beginner routine

Morning

Gentle cleanser (or rinse if you are dry)
Vitamin C (2 to 5 days per week at first)
Moisturizer
Broad-spectrum SPF

Night

Gentle cleanser
Moisturizer (thin layer)
Retinol or retinoid (start 2 nights per week)
Moisturizer again if needed (sandwich method)

How to increase without wrecking your barrier

Increase frequency before strength. Consistency matters more than the highest percentage.
Do not introduce a new exfoliating acid at the same time you start retinol.
If you peel or sting, reduce frequency and simplify for a week.
Always wear sunscreen. Retinoids can increase sun sensitivity.

Who should be extra cautious

Very sensitive or eczema-prone skin
People using prescription acne treatments
Anyone with recent chemical peels or aggressive treatments
Pregnancy or breastfeeding: avoid retinoids unless your clinician says otherwise

Quick wrap-up

Start when you can be consistent. Vitamin C is usually easier to begin earlier. Retinol can start in the mid 20s to early 30s for prevention, or earlier for acne with guidance. Go slow, protect your barrier, and never skip sunscreen.